The Hindu Cryptic on Sunday No 17, Dr. X

ACROSS

1   Most raunchy in cruise around river Seine on vacation (8) COARSEST {COA{R}{SeinE}ST}

5   Analysed acids containing phosphorus in protein shell of virus (6) CAPSID {CA{P}SID*}

10 Put down plane in river (7) DEFLATE {DE{FLAT}E}

11 Dash to get hold of spray and insecticide (7) LINDANE {LIN{AND*}E}

12 Devastation around a city in China (5) RUIAN {RUI{A}N}

13 Souvenirs and Japanese liquor found in dungeons (9) KEEPSAKES {KEEP{SAKE}S}

14 Shift in normal routine that bowler might use? (6,2,4) CHANGE OF PACE [DD]

18 Be in latrine, suffering after eating starter of mushrooms non-stop (12) INTERMINABLE {BE+IN+LATRINE}* over {Mu...s}

21 Reserved hotel, nearly new, to host party (9) HUSBANDED {H}{US{BAND}ED}

23 Watching some hockey in ground (5) EYING [T]

24 Generally, associate used laser to tackle onset of uveitis (2,1,4) AS A RULE {A}{LASER*} over {Uv...s}

25 Worry about rebellious misdeed after consuming spirit and ecstasy (7) AGONISE {A}{SIN<=} over {GO and{E}

26 Masked leader of hoodlums died around noon (6) HIDDEN {Ho...s}{DIED*}{N}

27 Familiar with the experience of tottering outside bar (4,2,2) USED TO IT {OUTSIDE+T}* 

DOWN

1   Remarkably sacred trees (6) CEDARS*

2   Fling with female in a gala (6) AFFAIR {A}{F}{FAIR}

3   Fans upset about American songstress becoming more stout (9) STAUNCHER {NU{A}TS<=}{CHER}

4   Talk ambiguously of immorality involving top director and lady in trips (5,2,7) SPEAK IN RIDDLES {S{PEAK}IN}{RID{D}{L}ES}

6   Workers union breaking relations (5) AUNTS {A{U}NTS}

7   Bolt after fire engulfs new cafe (5,3) SNACK BAR {BAR}<=>{S{N}ACK}

8   Groom desires designer's latest to become more stylish (8) DRESSIER {DESIRES}*{d...eR}

9   Fully attentive as leader analyses blunders (3,4,3,4) ALL EYES AND EARS*

15 Lie in shade and fool around (9) FALSEHOOD {SHADE+FOOL}*

16 Confusion in motorway on island with accident outside hotel (8) MISHMASH {M}{I}{S{H}MASH}

17 Reportedly irritated as idiot is spilling alcohol heartily (2,2,4) IT IS SAID {AS+IDIoT+AS}*

19 Excellent youngster, close to pro in Japanese form of self-defence (6) AIKIDO {A1}{KID}{prO}

20 Old English king, say, and queen involved in venture (6) EGBERT {EG}{BE{R}T}

22 A laceration on back of knee is dangerous (5) ACUTE {A}{CUT}{kneE}

Reference List

River = R, Dungeons = KEEPS, Hotel = H, Associate = A, Ecstasy = E, Noon = N, Bar = T, Female = F, American = A, Director = D, Lady = L, Union = U, New = N, Motorway = M, Island = I, Queen = R