No 12684, Monday 22 Jul 2019, Dr. X

ACROSS
1   Crack, ecstasy and cocaine taken in depression by woman (8) DECIPHER {D{E}{C}IP}{HER}
5   Manage when callous husband abandons, having turned rotten (6) AFFORD {hA{OFF<=}RD}
10 Poor recital – scrapping it for sure (5) CLEAR RECitAL*
11 Go to bed, overwhelmed by shame, oddly uncommunicative (9) SATURNINE {ShA{TURN IN}mE}
12 Harassed daughter rose to tackle a thug (9) DRAGOONED {D}{R{A}{GOON}ED}
13 Reasons given by one in low spirits about consuming ecstasy (5) IDEAS {1}{SA{E}D<=}
14 It is an extensively consumed herbal infusion (6) TISANE [T]
15 Summon chap going round with concoction of tea (7) EVOCATE {COVE<=}{TEA*}
18 Time to go round fancy bar in marina (7) HARBOUR {H{BAR*}OUR}
20 Heartily requested girl in lake to come out (6) EMERGE {r..uEs..d}{MER{G}E}
22 Close to largely forlorn girl (5) ALONG {ALONe}{G}
24 Drunkard's corporation? (4,5) BEER BELLY [CD]
25 Put up a fight in haunt (4,5) HANG ABOUT  {HANG}{A}{BOUT}
26 Long for a bit of vodka in noisy pub (5) LOCAL {L}{vOCAL}
27 Girl about to bag right husband making money in Africa (6) DIRHAM {MAID<=} over {R}{H}
28 A serious setback! Congress starting to become insignificant (4,4) BODY BLOW {BODY}{Be...e}{LOW}

DOWN
1   Throw light on fish in river (6) DECODE {DE{COD}E}
2   Buck up after capturing most effective knight (9) CHEVALIER {CHE{VALId}ER}
3   Angrily pans one arrogant unacceptable individual (7,3,5) PERSONA NON GRATA*
4   Ultimately deplorable scenes around centre (7) ESSENCE {d...lE}{SCENES*}
6   Powerful ambition that a gastritis sufferer might have? (4,2,4,5) FIRE IN ONES BELLY [DD]
7   Suspect held by cop in enclosure (5) OPINE [T]
8   Smarter rogue desires to conceal a little romp (8) DRESSIER {DESIRES}* over {Romp}
9   Heavy food left out for good man in cottage (6) STODGE (-l+st)STODGE
16 Holy girl in unholy alliance (9) ANGELICAL {G} in {ALLIANCE}*
17 Covered shack retains warmth (8) SHEATHED {S{HEAT}HED}
19 Strip-tease by revolting toff (6) RIBBON {RIB}{NOB<=}
20 Prefer bringing back alternative style of dance music (7) ELECTRO {ELECT}{OR<=}
21 Regulation about abandoning construction of cableway (3-3) BYELAW caBLEWAY*
23 Landlord in a state of depression after losing daughter (5) OWNER dOWNER

Reference List

Ecstasy = E, Cocaine = C, Husband = H, Daughter = D, Girl = G, Long = L, Right = R, Left = L, Good man = ST, About = CA

GRID